General
Preferred name
ART558
Synonyms
P&D ID
PD164790
CAS
2603528-97-6
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Pol¦È inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer[1].
PRICE 551
DESCRIPTION ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Pol?? inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.
DESCRIPTION ART558 is a small-molecule inhibitor of DNA polymerase theta (POLθ) . It is suitable for in vitro investigations. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
8
Cayman Chemical Bioactives
42324
Chemical Probes.org
art558
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
12657
High-quality chemical probes
PD164790
MedChem Express Bioactive Compound Library
HY-141520
Selleckchem Bioactive Compound Library
art558
TargetMol Bioactive Compound Library
T9275
External IDs
8
Properties
(calculated by RDKit )
Molecular Weight
418.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.19
TPSA
80.46
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
DNA polymerase
DNA/RNA Synthesis
POLQ
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Target class
Enzyme
Target subclass
DNA Polymerase
Control
(2R,4R)-1-(3-Cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-4-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide
Source data